How OnabotulinumtoxinA “Revolutionized” Treatment of Urologic Conditions

Urology Times® is celebrating its 50th anniversary in 2022. To mark the occasion, we are highlighting 50 of the top innovations and developments that have transformed the field of urology over the past 50 years. In this installment, Melissa R. Kaufman, MD, PhD, FACS, discusses the significance of onabotulinumtoxinA treatment in patients with overactive bladder. Dr. Kaufman is a Professor of urology, Patricia and Rodes Hart Endowed Chair of Urologic Surgery, and Chief of Reconstructive Urology and Pelvic Health at Vanderbilt University Medical Center, Nashville, Tennessee. Read more.

Source: Urology Times, February 16, 2022

Sacral Neuromodulation, Botulinum Show Equal Efficacy

In patients with refractory urgency urinary incontinence (UUI), sacral neuromodulation (InterStim) and onabotulinumtoxinA (Botox) produce similar reductions in mean daily UUI episodes, according to 24-month follow-up data on patients treated in a randomized trial. Investigators in the ROSETTA (Refractory Overactive Bladder: Sacral NEuromodulation versus BoTulinum Toxin Assessment) trial in 2016 reported that botulinum toxin at 6 months of treatment resulted in a “small daily improvement in UUI episodes” that was statistically significant (JAMA 2016; 316:1366–74). Now, in long-term follow-up data on ROSETTA, NIH investigators reported at the International Continence Society annual meeting in Florence, Italy that the two treatments provide similar reductions in mean daily UUI episodes at 24 months. However, botulinum toxin treatment was more likely to provide complete resolution of episodes 6 months after treatment, and it was associated with higher patient satisfaction and treatment endorsement ratings over the 24 months, reported first author Christopher J. Chermansky, MD, assistant professor of urology at the University of Pittsburgh School of Medicine. Read more.

Source: Urology Times, November 14, 2017

Botulinum Toxin (BOTOX®) Injections

You and your doctor need to decide together if trying BOTOX is right for you.

Botulinum toxin (commonly called BOTOX®) is often used in cosmetic procedures. BOTOX is also a relatively new treatment for severe urge incontinence that has not responded to medical therapy. It is also for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency and frequency. It is only for use in adults who have had an inadequate response to, or are intolerant of, anticholinergic medication. In this treatment, BOTOX is injected directly into the bladder muscle, relaxing it and allowing the bladder to fill with more urine before the urge to urinate strikes.Continue reading→