medical research

Urology in the Lab: Researchers link EBV to Multiple Sclerosis

Urology in the Lab starts off with data from a study that very strongly implicates Epstein-Barr virus (EBV) as the causative agent underlying multiple sclerosis (MS), a demyelinating disease that often finds its way into the urology clinic due to neurogenic bladder that can develop during the course of disease. Read more.

Urology Times, November 27, 2023

product approval introduction

Ipsen Receives Positive Opinion In Europe for Dysport® In the Management of Urinary Incontinence In Adults With Neurogenic Detrusor Overactivity Due to Multiple Sclerosis or Spinal Cord Injury

Ipsen (Euronext: IPN; ADR: IPSEY) today announced that Dysport® (abobotulinumtoxinA) has received positive opinion in Europe for the management of urinary incontinence (UI) in adults with neurogenic detrusor overactivity (NDO) due to spinal cord injury (SCI) (traumatic or non-traumatic) or multiple sclerosis (MS), who are regularly performing clean intermittent catheterization (CIC).  This positive opinion for Dysport® now permits individual European country Health Authorities to grant national approvals, according to their country regulations.  In addition, Ipsen is also currently in the process of obtaining approvals in other countries outside the European Union. Read more.

Source: Globe Newswire, June 9, 2022

imaging brain head

Incontinence in MS Affects Walking Ability, Negatively Impacts Patients’ Quality of Life, Study Finds

Urinary incontinence,  associated with poor functioning of the muscles in the pelvic area, was found to have a negative impact on daily activities like walking and overall quality of life in people with multiple sclerosis (MS), a study shows. Adding pelvic floor muscle training to an MS treatment program may help to improve overall function, the researchers suggest, which could improve patient performance of daily life activities, especially in those with moderate or severe dependence on others. The study, “Pelvic floor dysfunction negatively impacts general functional performance in patients with multiple sclerosis,” was published in the journal Neurology and Urodynamics. Read more.

Source: Multiple Sclerosis News Today, February 18, 2020

imaging brain head

Certain Sites of Brain Lesions in MS Tied to Bowel Incontinence

Specific locations of cerebral multiple sclerosis lesions appear to be associated with bowel incontinence, according to a study published online Dec. 11 in the Journal of Neuroimaging.  Kilian Frohlich, M.D., from the University Hospital Erlangen in Germany, and colleagues used a voxel-wise lesion symptom mapping analysis to assess associations between bowel incontinence and cerebral multiple sclerosis lesions identified on magnetic resonance imaging of 51 patients. The researchers found associations between fecal incontinence in a total of 93 lesioned voxels, with 63 voxels located in the gray matter and 30 voxels in the white matter.  Read more.

Source: Practice Update, December 17, 2018

spine anatomy

Astellas Wins Expanded Label to Include Pediatric Use for Oral Solifenacin in the EU

Tokyo-based Astellas Pharma (TYO: 4503) has been awarded EU approval for its neurogenic detrusor overactivity (NDO) therapy solifenacin succinate in oral suspension form. The drug is indicated for children aged 2 to 18 years.  NDO is a bladder dysfunction in which increased storage pressure can put the upper urinary tract at risk of deterioration.  Commonly observed in patients with conditions such as multiple sclerosis and spinal cord injury, it causes urinary incontinence in approximately 50% of MS patients. Read more.

Source: The Pharma Letter, March 9, 2018