imaging brain head

Certain Sites of Brain Lesions in MS Tied to Bowel Incontinence

Specific locations of cerebral multiple sclerosis lesions appear to be associated with bowel incontinence, according to a study published online Dec. 11 in the Journal of Neuroimaging.  Kilian Frohlich, M.D., from the University Hospital Erlangen in Germany, and colleagues used a voxel-wise lesion symptom mapping analysis to assess associations between bowel incontinence and cerebral multiple sclerosis lesions identified on magnetic resonance imaging of 51 patients. The researchers found associations between fecal incontinence in a total of 93 lesioned voxels, with 63 voxels located in the gray matter and 30 voxels in the white matter.  Read more.

Source: Practice Update, December 17, 2018

spine anatomy

Astellas Wins Expanded Label to Include Pediatric Use for Oral Solifenacin in the EU

Tokyo-based Astellas Pharma (TYO: 4503) has been awarded EU approval for its neurogenic detrusor overactivity (NDO) therapy solifenacin succinate in oral suspension form. The drug is indicated for children aged 2 to 18 years.  NDO is a bladder dysfunction in which increased storage pressure can put the upper urinary tract at risk of deterioration.  Commonly observed in patients with conditions such as multiple sclerosis and spinal cord injury, it causes urinary incontinence in approximately 50% of MS patients. Read more.

Source: The Pharma Letter, March 9, 2018