pregnancy woman childbirth

A Muscle-Regenerating Gel Aims to Treat Pelvic Floor Dysfunctions

In vaginal childbirth, the pelvic muscles are subjected to tremendous stretching and can suffer damage, e.g., tears. These injuries can lead to pelvic floor disorders such as pelvic organ prolapse and urinary and fecal incontinence. The most common treatment option is rehabilitation, although in acute cases surgery may be necessary. However, the damaged fibers do not recover, says Pamela Duran, a bioengineer at the University of California. She and her team have created a hydrogel based on an extracellular matrix extracted from pigs, which has succeeded in regenerating the affected tissue. The results of the research, which was conducted in rats, were recently published in the journal Science Translational Medicine. Read more.

Source: El Pais, October 30, 2023

stem cell tissue regeneration

USC Viterbi Researcher’s Work Seeks to Help Those Who Really Have to Go

Tissue regeneration gets the attention of Eun Ji Chung, a USC researcher who also studies a common and distressing problem: bladder control.  Chung, an assistant professor at the USC Viterbi School of Engineering, examines how tissue regeneration could help patients with urinary incontinence caused by the loss or weakened control of the muscle controlling the release of urine from the bladder. The problem affects millions, especially women and females who have given birth. She hopes to provide a solution by restoring urethral tissue form and function. The goal: to develop biocompatible and bioactive hydrogels that can release growth factors and stimulate muscle repair using adipocytes, or fat stem cells, for the urethra, she said. Read more.

Source: USC News, February 13, 2017